In 1958, Cremer had demonstrated that serum bilirubin concentration of new born infant can be reduced by exposure to light. There were many reports about the effect of phototherapy on hyperbilirubinemia and premature baby.
A controlled clinical trial has been carried out among 48 full term infant who were selected by random sampling to test the effectiveness of artificial 300 foot candle white fluorescent light in normal physiologic jaundice. Twenty four (Male11, Femal 13) control group and 24 (Male 11, Female 13) phototherapy group were divided alternately. Infant in phototherapy group were exposed to light (Apart with the light source about 100 cm above the infant) starting in the first 24 hours of life, usually in the first 8 hours and continued for 3 days except feeding time and parent visiting time which may be mounted to 5 or 6 hours a day. The infant were unclothed except for a eye cover and diaper. Infant in the control group were managed in the same manner, except exposure to light. All infants with pathologic conditions were excluded. Blood samples were collected in Natelson microblood collecting tubes by heel puncture daily using the tip of a No. 11 blade. Approximately 0.1 ml to 0.2 ml of serum was obtained and bilirubin level determined by the method of Hsia and Associates.
The following results were obtained. The bilirubin levels of the cord blood shows no significant difference between two groups and its average is 0.8 ㎎/dl. The serum bilirubin levels of the phototherapy group is 4.050 ±0.362 ㎎/dl on Day 1,6.591±0.366 ㎎/dl on Day 2, 7.0±0.844 ㎎/dl on Day 3. The serum bilirubin levels of the control group is 5.720±0.442 on Day 1, 7.608±0.421 ㎎/dl on Day 2, 9.164±0.836 ㎎/dl on Day 3. (Listed on Table 3). The mean serum bilirubin values of the phototherpay group were lower than those of the control group 0.870 ㎎/dl on Day 1, 1.007 ㎎/dl-on Day 2, 2.164 ㎎/dl on Day 3.
1) The rise in Bilimbin over the base level in phototherapy group was 4.033±0.424 ㎎/dl on Day 1, 5.595±0.378 ㎎/dl on Day 2, and 7.123±0.428 ㎎/dl on Day 3. (Listed on table5).
2) The rise in bilirubin over the base level of the phototherapy group were significantly lower than control group on Day 1 (P value<0.025), on Day 2 (P value<0.1). and on Day 3 (P value<0.025).
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